Safety, Three Batches Consistency and Immunity Duration of the Post-marketing Inactivated Enterovirus Type 71 (EV71) Vaccine in Children Aged 6-71 Months

Inclusion Criteria: * 8 Months to 71 Months (Healthy Children or Infants)； * Providing the subjects' legal identity certificate (birth certificate , residence booklet or ID card) and vaccination certificate, legal guardians can provide legal identity proof (resident booklet or ID card) so that the doctor can determine the subject identity to complete recruitment program； * The subjects' guardians are able to understand and sign the informed consent voluntary. Guardians have the ability to use the thermometer ,dividing ruler and can fill out the Diary card ,follow-up card according to requirements； * Persist for a 24 months visit.If doubtful HFMD case happen，the subject's guardian should send the subject to the medical institutions at above the county level and report this case to the investigator.The subjects who participate immunogenicity observation group can receive sample collection including blood，throat swab or anal awab according to program requirements. Exclusion Criteria: * Exclusion Criteria for the first dose: * Subject with clinical diagnosis or suspect HFMD（Especially the history of herpangina）； * Subject that has a medical history of any of the following: allergic history, or allergic to any ingredient of vaccine； * History of seizures,convulsions or twitching ;Family history of progressive neurological disease； * Autoimmune disease or immunologic deficiency.Any prior administration of immunodepressant in last 6month； * History of asthma，thyroid ablation，angioneurotic edema, diabetes mellitus or malignant tumour； * Alienia，functional asplenia，or any condition that cause asplenia or splenectomy； * Diagnosed coagulation abnormalities (such as clotting factor deficiency, coagulation disorders, platelet disorder) or significant bruising or blood clotting disorder； * Any acute disease or chronic disease attack in last 7 days； * Any prior administration of blood products in last 3 month； * Any prior administration of attenuated live vaccine in last 15 days , subunit or inactivated vaccines in last 7 days； * Fever before vaccination, axillary temperature ﹥37.0℃； * Attend Other vaccine or drug clinical trials concurrent in 6 months； * Any condition that in the opinion of the investigator。 * Exclusion Criteria for the second dose: * Any exclusion criteria for the first dose happens after been enrolled； * Newly HFMD diagnosed patients after been enrolled； * Any condition that in the opinion of the investigator or ethics committee think should be eliminated.