The Circulating Cell-free Genome Atlas Study

Inclusion Criteria for Non-Cancer Arm Participants: * Age 20 years or older * Able to provide a written informed consent Exclusion Criteria for Non-Cancer Arm Participants: * Known current or prior diagnosis of cancer except non-melanoma skin cancer * Oral or IV corticosteroid use in past 14 days prior to blood draw * Pregnancy (by self-report) * Current febrile illness * Acute exacerbation or flare of an inflammatory condition requiring escalation in medical therapy within 14 days prior to blood draw. * Recipient of organ transplant or prior non-autologous (allogeneic) bone marrow or stem cell transplant * Poor health status or unfit to tolerate blood draw Inclusion Criteria for Cancer Arm Participants: * Age 20 years or older * Able to provide a written informed consent Have either of the following: A. Confirmed cancer diagnosis (any stage I-IV, as well as carcinoma in situ (CIS) within 90 days prior to or up to 42 days after study blood draw, based upon assessment of a pathological specimen OR B. A high suspicion for a cancer diagnosis by clinical and/or radiological assessment, with planned biopsy or surgical resection to establish a definitive diagnosis within 6 weeks (42 days) after study blood draw Exclusion Criteria for Cancer Arm Participants: * Known prior diagnosis of cancer except non-melanoma skin cancer * Currently receiving, or ever received, any of the following therapies to treat their current cancer: surgical management of the cancer beyond that required to establish the cancer diagnosis; local, regional or systemic chemotherapy including chemoembolization; targeted therapy, immunotherapy including cancer vaccines; hormone therapy; or radiation therapy * Pregnancy (by self-report) * Current febrile illness * Acute exacerbation or flare of an inflammatory condition requiring escalation in medical therapy within 14 days prior to blood draw. * Recipient of organ transplant or prior non-autologous (allogeneic) bone marrow or stem cell transplant * Poor health status or unfit to tolerate blood draw