The investigators will investigate whether the night guard can suppress the development of recurrent aphthous stomatitis (RAS). The investigators will record the patients' oral condition for 60 days before and after intervention with the night guard made of Ethylene-Vinyl Acetate copolymer (EVA). The patients' saliva will be analyzed for measurement of inflammatory cytokines or oxidative stress.
The study involved 20 patients (8 male and 12 female) with RAS. These patients suffered from RAS at least once a month. The investigators will record their oral condition for 60 days before and after intervention with the night guard made of EVA. Their saliva will be analyzed for further studies including measurement of inflammatory cytokines or oxidative stress.
Study Type
INTERVENTIONAL
Allocation
NON_RANDOMIZED
Purpose
PREVENTION
Masking
SINGLE
Enrollment
20
60 days before and after intervention with the night guard
60 days before and after intervention with the placebo night guard
Tada Dental Clinic
Kakogawa, Hyōgo, Japan
Tokushima University Hospital
Tokushima, Japan
number of developed aphthous stomatitis
Time frame: through study completion, an average of 1 year
days until healing
Time frame: through study completion, an average of 1 year
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