Efficacy and Safety of Ethanol Lock Therapy for the Prevention of Central Line-associated Bloodstream Infections

Stanford University3 enrolled

Overview

Patients on long-term parenteral nutrition (PN) are at high risk for central line-associated bloodstream infections (CLABSI). This study evaluates the efficacy and safety of ethanol lock therapy for CLABSI prophylaxis in adult patients on PN.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

QUADRUPLE

Enrollment

Conditions

Catheter-Related Infections

Interventions

Ethanol lockOTHER

Heparin lockOTHER

Eligibility

Sex: ALLMin age: 18 YearsMax age: 80 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Adult patients (ages 18-80) on PN with silicone-based central venous catheters Exclusion Criteria: * Weight ≤ 50 kg * Allergy/hypersensitivity/intolerance to ethanol or heparin * Pregnancy or breastfeeding * Patient taking metronidazole, disulfiram, or isoniazid * History of alcohol abuse * History of heparin-induced thrombocytopenia (HIT) or have an active hypocoagulable state

Locations (1)

Stanford University

Palo Alto, California, United States

Outcomes

Primary Outcomes

Central line-associated bloodstream infection

Time frame: 12 months

Secondary Outcomes

Hospitalization

Time frame: 12 months

SIRS/sepsis

Time frame: 12 months

Catheter-related complication

Time frame: 12 months

New self-reported symptoms

Time frame: 12 months

Data from ClinicalTrials.gov

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