Effect of Hyperbaric Oxygen on Functional Connectivity in Patients With Cerebral Small Vessel Disease

Inclusion Criteria: * White Matter Hyperintensities on MRI * 2 or more neurological symptoms or impairments e.g. gait disturbances, disequilibrium, cognitive decline, dysmetria, hyper-rflexia Exclusion Criteria: * Contraindication to hyperbaric oxygen treatment e.g. pulmonary emphysema, seizure disorder * major eustachian tube dysfunction * stroke with previous 6 months * extreme cognitive impairment * major depression * history of migraine, electroshock therapy, brain irradiation, brain tumor, head trauma * other uncontrolled co-morbidities, e.g. diabetes, renal or hepatic dysfunction, hypertension, thyroid disorders, carotid artery stenosis (\>70%)