Multiple Dose Study of SHR4640 in Healthy Subjects

Inclusion Criteria: 1. Age between 18 and 55, male; 2. Body weight≥50, BMI:19-25kg/m2; 3.4 mg/dL≤Screening serum urate level≤7 mg/dL; 4.Medically stable based on physical examination, laboratory results, vital sign measurements, 12-lead electrocardiogram, abdomen B-ultrasound and Chest X-ray examination at screening. Exclusion Criteria: 1. Serum creatinine\>upper limits of normal(ULN); 2. Alanine aminotransferase and/or Aspartate aminotransferase\>2×ULN, total bilirubin\>1.5×ULN, glutamyltransferase\>3×ULN; 3. History of hyperuricemia or gout; 4. History or suspicion of kidney stones; 5. Positive results for hepatitis B surface antigen, hepatitis C antibody, HIV antibody, syphilis antibody test.