The chronic immune thrombopenia is an autoimmune disease caused by B cells. These cells produce anti platelets and megakaryocytes antibodies. Some B cells, named regulatory B cells, are known to control other cells. Their action in chronic immune thrombopenia is actually unknown.
The chronic immune thrombopenia is an autoimmune disease caused by B cells. These cells produce anti platelets and megakaryocytes antibodies. Some B cells, named regulatory B cells, are known to control other cells. Their action in chronic immune thrombopenia is actually unknown. In our cohort of chronic immune thrombopenia and controls, we realized a flow cytometry analyze of B and T cells and a co-culture to determine regulatory B cells functionality.
Study Type
OBSERVATIONAL
Enrollment
36
From the blood: B and T cells extraction then co-culture B and T cells and characterization of lymphocytes by flow cytometry
CHRU de Brest
Brest, France
Regulatory B cells functionality
inhibition of T cells proliferation with co-culture B and T cells
Time frame: 1 week
Cytometry immunophenotyping of B and T cells
characterization of B and T cells by flow cytometry
Time frame: 1 week
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