The mechanism of bone loss in anorexia nervosa is complex. Marrow adipose tissue seems to play a role in the regulation of bone metabolism. Adipocytes secrete cytokines and adipokines that either stimulate or inhibit adjacent osteoblasts. This study consist to explore the relationship in anorexia nervosa patients with change in bone mineral density and adipokines like leptin, adiponectin and Préf-1 Bone mineral densities will be measure in 180 anorexia nervosa patients at inclusion and every two years during 6 years.It is assessed blood and urinary calcium and phosphate levels, bone remodelling markers and adipokines (leptin, adiponectin and Préf-1)
Study Type
OBSERVATIONAL
Enrollment
180
The Dual Energy X-ray Absorptiometry (DEXA) is a third generation multi-captor DEXA device that allow short duration measurements. It measures Bone Mineral Density (BMD) at the spine and the femoral neck
Hôpital Roger Salengro, CHRU de Lille
Lille, France
Bone mineral density by Dual Energy X-ray Absorptiometry (DEXA)
measured the evolution of the bone mineral density in 180 anorexia nervosa patients and the relationship with this change and adipokine
Time frame: 4 years
Incidence of osteoporotic fractures
Time frame: at 2,4 and 6 years
Adiponectin plasma concentration by ELISA
measurement of circulating biological factors predicative of changes in BMD
Time frame: at 2,4 and 6 years
Interleukin-7 plasma concentration by ELISA
measurement of circulating biological factors predicative of changes in BMD
Time frame: at 2,4 and 6 years
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