The Influence of Sweet Substrates on Hunger, Gastrointestinal Hormones and the Migrating Motor Complex

Universitaire Ziekenhuizen KU Leuven12 enrolled

Overview

In this study, the investigators aimed at evaluating the role of sweet taste receptors in the gastrointestinal tract (GIT). Intragastric administration of glucose, fructose or acesulfame-K were compared with placebo administration for their effects on gastrointestinal motility, gut hormone release (motilin, ghrelin, glucagon-like peptide-1 (GLP-1) and insulin) and hunger feelings.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

DOUBLE

Enrollment

Conditions

Healthy

Interventions

50g glucoseDIETARY_SUPPLEMENT

25g fructoseDIETARY_SUPPLEMENT

220mg acesulfame-KDIETARY_SUPPLEMENT

250mL tap waterDIETARY_SUPPLEMENT

Eligibility

Sex: ALLMin age: 18 YearsMax age: 60 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * BMI\<30 kg/m² for the lean volunteers * Female or male subjects aged 18 to 60 * Subject is capable and willing to give informed consent * Female volunteers of child bearing potential must use oral, injected or implanted hormonal methods of contraception Exclusion Criteria: * Female volunteer is pregnant or breastfeeding * GI diseases, major abdominal surgery * Volunteers that have food allergies, especially fructose intolerance * Major psychiatric illnesses * Volunteers that use drugs affecting the GI tract or the central nervous system * Volunteers suffering from an endocrine disease such as diabetes, Cushing's disease, Addison's disease, hypothalamic tumor * Volunteers that have undergone surgical procedure for weight loss

Outcomes

Primary Outcomes

Change in gastrointestinal motility measured by antroduodenal high-resolution manometry

Time frame: 3 hours after administration, continuous measurement with high resolution manometry

Secondary Outcomes

Change in gut hormone release measured by specific radioactive immunoassays

Time frame: 3 hours after administration, blood sample every 15 min

Change in subjective hunger and satiety scores measured by visual analogue scales of 100 mm

Time frame: 3 hours after administration, assessment every 5 min

Data from ClinicalTrials.gov

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