KERatoconus and Metalloproteinases InvesTigation

Fondation Ophtalmologique Adolphe de Rothschild23 enrolled

Overview

Corneal stromal thinning observed in keratoconic eyes could result from an increased synthesis of MMP at the level of the anterior stroma and the corneal epithelium induced by an overexpression of the Extracellular Matrix Metalloproteinase Inducer (EMMPRIN) and Galectin-3 by epithelial cells. A differential expression of EMMPRIN, Galectin-3 and metalloproteinases (MMP) may be observed between the apex of the keratoconus and the peripheral cornea. Highlighting the implication of EMMPRIN and Galectin-3 could lead to the development of specific inhibitors to slow or to stop keratoconus evolution.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Keratoconus

Interventions

immuno-histo-chemical analysisOTHER

in vitro immuno-histo-chemical analysis of corneal epithelium

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * age \> 18 years old * Patient with keratoconus undergoing corneal collagen cross-linking (epithelium-off methods) * Patient with keratoconus undergoing his first corneal graft for optical indication (control) Exclusion Criteria: * Patient with keratoconus undergoing corneal graft for tectonic indication * Patient undergoing corneal refractive surgery (refractive photokeratectomy) with a normal topography, a normal slit lamp examination and no previous ophthalmic condition (control) * pregnant or breast feeding patient * patient under judiciary protection * patient opposition to participate in the study

Locations (1)

Fondation Opthalmologique A de Rothschild

Paris, France

Outcomes

Primary Outcomes

expression of the Extracellular Matrix Metalloproteinase Inducer (EMMPRIN) in epithelial cells

Time frame: baseline

Data from ClinicalTrials.gov

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