Cannabis Versus Oxycodone for Pain Relief

Overall Inclusion Criteria: * Previous smoked or vaporized cannabis exposure * Age ≥21 years Overall Exclusion Criteria: * Current substance use disorder * Current alcohol use disorder * Past cannabis abuse/dependence * Current use of amphetamine/methamphetamine, barbiturates, benzodiazepines, cocaine, phencyclidine (PCP), MDMA (ecstasy) * Prior adverse reaction to cannabis exposure (paranoia, anxiety, etc.) * Allergy to or prior adverse reaction to oxycodone * Any condition contraindicative to opioid use (e.g. paralytic ileus) * History or diagnosis of schizophrenia or bipolar disorder * Current severe depression * Uncontrolled hypertension (\>139/89) * Known cardiovascular disease * Known immune system disorder * Chronic pulmonary disease (e.g., bronchitis, asthma, COPD, or emphysema) * History of seizure disorder * Diagnosed inflammatory disease (e.g. Rheumatoid Arthritis (RA)) * Clinically significant abnormal values on CBC/CMP/EKG tests * Cognitive disability that interferes with ability to provide consent or understand study procedures * Inability to refrain from using tobacco for at least 4 hours * Pregnant females * Lactating females Additional Exclusion Criteria for SPINE PATIENTS * Current regular use of a long acting opioid (e.g. OxyContin, MS Contin, other extended release formulas) * Current high-dose use of immediate release opioid * Current high-dose use of nerve-targeted medication * Other diagnosed chronic pain syndromes of greater severity than spine condition (e.g. knee pain ) * Diagnosed Fibromyalgia * Neuropathy not associated with spine condition (e.g. diabetic neuropathy) Additional Exclusion Criteria for HEALTHY CONTROLS * Current acute pain * Current chronic pain condition (e.g. fibromyalgia, neuropathy)