The dissemination of individual tumor cells is a common phenomenon in solid cancers. Detection of tumor cells in peripheral blood circulating tumor cells (CTC) in nonmetastatic situation is of high prognostic significance. The objective of our study was to detect circulating tumor cells in two different method in patient with head and neck squamous cell carcinoma .
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
BASIC_SCIENCE
Masking
NONE
Enrollment
40
Patients with stage III and IV head and neck squamous cell carcinoma undergoing surgery were enrolled in this study 5 and 7.5 ml of peripheral venous blood will be taken before the surgery, just at the end of surgery and one week after surgery Analysis was performed by RT-PCR and the CellSearch™ method using immunomagnetic and fluorescence approaches. Patients will be followed every 3 months for two years.
Institut de Cancérologie de Lorraine
Vandœuvre-lès-Nancy, France
Circulating tumor cells in peripheral blood during head and neck surgery
The number of circulating tumor cells detected per milliliter of peripheral blood will be evaluated on the day before, the day of surgery and 7 days after the surgery.
Time frame: 7 days
Comparison between RT-PCR and CellSearch™ method
The comparison between RT-PCR and CellSearch™ method will be the positivity sample rate
Time frame: 1 day
Prognostic marker of relapse
Local recurrence, regional or metastatic head and neck cancer in the two years
Time frame: 2 years
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