The purpose of this study is to evaluate the safety and immunogenicity of LBVE013 (Pneumococcal 13-valent conjugate vaccine \[diphtheria CRM197 protein\]) or LBVE014 (Pneumococcal 14-valent conjugate vaccine \[diphtheria CRM197 protein\]) in healthy adults.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
SINGLE
Enrollment
63
Seoul National University Hospital
Seoul, South Korea
Solicited adverse events
Time frame: Baseline(pre-vaccination) up to 7 days after vaccination
Unsolicited adverse events
Time frame: Baseline(pre-vaccination) up to 4 weeks after vaccination
Immediate reactions after vaccination
Time frame: Baseline(pre-vaccination) up to 30 minutes after vaccination
Serotype-Specific Pneumococcal Opsonophagocytic Activity (OPA) Geometric Mean Titers (GMTs) 4 weeks After Vaccination
Time frame: 4 weeks after vaccination
Proportion of subjects achieving 4-fold rise in Pneumococcal Opsonophagocytic Activity (OPA) titer at 4 weeks after vaccination
Time frame: 4 weeks after vaccination
Serotype-Specific Pneumococcal IgG antibody Geometric Mean Concentrations (GMCs) 4 weeks After Vaccination
Time frame: 4 weeks after vaccination
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