A Study to Evaluate the Safety and Efficacy of Humia Inj. in Patients With Symptomatic Osteoarthritis of the Knee

Inclusion Criteria: * Primary knee osteoarthritis confirmed clinically and radiologically according to American College of Rheumatology criteria have joint pain * Kellgren-Lawrence Grade Ⅰ to Ⅲ confirmed radiologically within 6 months * Knee pain under weight-bearing pain(100mm-VAS) greater than 40mm * Able to walk without assistive devices * Patients willing and able to provide signed informed consent after the nature of the study has been explained Exclusion criteria: * Body Mass Index (BMI) \> 32 * History of rheumatoid arthritis or other inflammatory arthritis in knee articular cavity * Systemic Intravenous Steroid injection within 1 month, intra-articular corticosteroid injection within 3 months or hyaluronate injection within 6 months * Has clinically severe tense effusion of the target knee diagnosed Positive according to Patella tap test * Undergo Knee Replacement Surgery of the target knee