Antihypertensive Treatment in Masked Hypertension

Inclusion Criteria: 1. Age 30-70 years old 2. Masked hypertension patients, defined as clinic BP\<140/90 mmHg, while 24h ambulatory BP ≥130/80 mmHg and (or) daytime BP ≥135/85 mmHg and (or) nighttime BP ≥120/70 mmHg 3. Combined with at least one kind of target organ damage: left ventricular hypertrophy (Cornell voltage combination ≥2440mm·ms or Sokolow-Lyon index ≥4.0mv for male and 3.5mv for female), large arterial stiffness (brachial-ankle pulse wave velocity ≥1400cm/s) and microalbuminuria (twice random urine microalbuminuria/creatinine ratio ≥2.5mg/mmol for male and 3.5mg/mmol for female). 4. Didn't use any anti-hypertension drugs within 2 weeks 5. Be willing to participate in the trials and able to finish clinic visits Exclusion Criteria: 1. Under antihypertensive treatment 2. Secondary hypertension 3. Taking other medications that may influence BP 4. Sleep apnea syndrome 5. Diabetes combined with microalbuminuria 6. Renal parenchymal disease, such as chronic nephritis, polycystic kidney 7. Occurrence of coronary heart disease, myocardial infraction or stroke within 6 months 8. Structural heart disease, such as hypertrophic cardiomyopathy, dilated cardiomyopathy 9. Alanine transaminase (ALT), aspartate transaminase (AST), total bilirubin (TBL) upper the twice of normal range, serum creatinine (Scr)≥2.0mg/dl, plasma hypokalemia≥5.5mmol/L, 10. Patients have contraindications to angiotensin receptor blockers (ARBs)