Study of the Influence of the Expression of the Calcium-sensitive Receptor (CaSR) by Monocytes in the Synovial Liquid on Structural Alterations in Patients Diagnosed With Rheumatoid Arthritis in the Previous Two Years

Centre Hospitalier Universitaire, Amiens42 enrolled

Overview

Rheumatoid arthritis (RA) is the most frequent form of chronic inflammatory rheumatism in adults. The erosive damage influences the functional prognosis in patients with RA. At present, there are no sufficiently sensitive and specific predictive markers of erosive damage.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Arthritis, Rheumatoid

Interventions

bloodBIOLOGICAL

measurement of CaSR expression levels on synovial fluid monocytes

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Patients consulting in the Department of Rheumatology at Amiens University Hospital * Age ≥ 18 * RA meeting the 2010 ACR/EULAR criteria * Less than 2 years of RA progression * Effusion in at least 1 joint Exclusion Criteria: * Inability to give informed consent * Ongoing pregnancy * Previous treatment with an anti-osteoporosis medication * Intra-articular corticoid or hyaluronic acid injection in the previous 6 months * Coagulation disorders preventing arthrocentesis * Incarceration or legal guardianship

Locations (1)

CHU Amiens

Amiens, France

Outcomes

Primary Outcomes

CaSR expression rate level on synovial monocytes

measured by flow cytometry

Time frame: 1 year

Data from ClinicalTrials.gov

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