Normal and Abnormal ERP During ToM and Emotional Conflicts in Schizophrenia

Versailles Hospital100 enrolled

Overview

Case-control comparison of clinical population, interventional and single-center research.

The main objective of this study is to define and characterize electrophysiological markers of the existing social cognition disorders in schizophrenia. Two groups of subjects are recorded : schizophrenic patients and healthy controls. Visual reinforcement effect during theory of mind judgment is tested.

Study Type

INTERVENTIONAL

Allocation

NON_RANDOMIZED

Purpose

DIAGNOSTIC

Masking

NONE

Enrollment

100

Conditions

Schizophrenia

Interventions

Theory of mind without visual cuesBEHAVIORAL

Theory of mind stimulation without visual reinforcement while performing EEG recordings

Theory of mind without visual cuesBEHAVIORAL

Theory of mind stimulation with visual reinforcement while performing EEG recordings

Eligibility

Sex: ALLMin age: 18 YearsMax age: 60 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: Written informed consent French mother tongue Schizophrenia diagnosis according to DSM-IV-R for the patient group Exclusion Criteria: Coma history, epilepsy, head trauma with loss knowledge greater 10 min ECT older than 1 month DSM-4 R criteria of toxic addiction in the last 6 months Deafness or blindness Scalp pathology Intracranial implanted device

Locations (1)

Centre Hospitalier de Versailles

Le Chesnay, France

Outcomes

Primary Outcomes

Event related electric amplitudes

Scalp EEG recordings (microvolts) with respect to average or vertex references

Time frame: Day 0

Data from ClinicalTrials.gov

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