The Effects of Perioperative Dexmedetomidine Administration on Immune Suppression and Outcomes in Patients With Uterine Cancer Undergoing Radical Resection

Yonsei University100 enrolled

Overview

Surgical stress and anesthesia may cause immunosuppression in immunocompromised cancer patients. The natural killer (NK) cell is a critical part of anti-tumor immunity. Dexmedetomidine has sympatholytic effect and preserves NK cell function. This study investigate the effect of dexmedetomidine on immune suppression and postoperative outcomes in patients undergoing uterine cancer resection.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

OTHER

Masking

TRIPLE

Enrollment

100

Conditions

Uterine Cancer

Interventions

Dexmedetomidine groupDRUG

dexmedetomidine infusion (0.4 mcg/kg/h) from immediately after anesthetic induction to 24 h after surgery

Control groupDRUG

0.9% saline infusion

Eligibility

Sex: FEMALEMin age: 20 YearsMax age: 70 Years

Medical Language ↔ Plain English

Inclusion Criteria: * patient between 20 and 70 of age with ASA physical status Ⅰ-Ⅲ * patient scheduled for uterine cancer surgery Exclusion Criteria: * ASA physical status Ⅳ * severe hepatorenal disease * infection * metastasis to other organ * problem with communication

Locations (1)

Department of Anesthesiology and Pain Medicine, Anesthesia and Pain Research Institue, Yonsei Universiy College of Medicine

Seoul, South Korea

Outcomes

Primary Outcomes

natural killer cell cytotoxicity

Natural killer cell cytotoxicity is measured with NK Vue Kit™(ATGen, Gyeonggi-do, Korea).

Time frame: 1 minute before surgery

natural killer cell cytotoxicity

Natural killer cell cytotoxicity is measured with NK Vue Kit™(ATGen, Gyeonggi-do, Korea).

Time frame: postoperative day 1

natural killer cell cytotoxicity

Natural killer cell cytotoxicity is measured with NK Vue Kit™(ATGen, Gyeonggi-do, Korea).

Time frame: postoperative day 3

natural killer cell cytotoxicity

Natural killer cell cytotoxicity is measured with NK Vue Kit™(ATGen, Gyeonggi-do, Korea).

Time frame: postoperative day 5

Secondary Outcomes

inflammatory response

inflammatory response is assessed by measuring levels of proinflammatory cytokines.

Time frame: 1 minute before surgery

inflammatory response

inflammatory response is assessed by measuring levels of proinflammatory cytokines.

Time frame: postoperative day 1

inflammatory response

inflammatory response is assessed by measuring levels of proinflammatory cytokines.

Time frame: postoperative day 3

inflammatory response

inflammatory response is assessed by measuring levels of proinflammatory cytokines.

Data from ClinicalTrials.gov

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