Neuronal Excitability of HCN1 Channel Mutations in Dravet Syndrome

Fondation Ophtalmologique Adolphe de Rothschild92 enrolled

Overview

This study addresses the changes in the axonal excitability parameters. It will compare these changes in patients with early infantile epileptic encephalopathy with HCN1 channel mutation and in control patients, with and without epilepsy.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Dravet Syndrome

Interventions

measure of neuronal excitabilityDEVICE

Eligibility

Sex: ALLMin age: 15 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * early infantile epileptic encephalopathy with HCN1 channel mutation * control patients with no neurologic pathology (age, gender and body temperature matched) * epileptic patients (age, gender and body temperature matched) Exclusion Criteria: * pregnant or breast feeding patient

Locations (1)

Fondation Ophtalmologique Adolphe de Rothschild

Paris, France

Outcomes

Primary Outcomes

hyperpolarizing electrotonus

Time frame: baseline

hyperpolarizing threshold current

Time frame: baseline

Data from ClinicalTrials.gov

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