Patients with mechanical ventilation are in risk of malnutrition, which could lead to worse outcome. According to guidelines released from authority organizations, enteral nutrition (EN) should be prior approach for critically ill patients. However, initiation and delivery of EN during the early period of ICU admission are frequently hampered, which results in underfeeding. The investigators speculate whether an intensive enteral nutrition strategy could reinforce the delivery of EN thereby improving outcomes. In this multi-center, prospective, randomized parallel clinical trial, the investigators aim to assess the feasibility, safety and outcomes of intensive enteral nutrition in mechanical-ventilated patients.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Enrollment
400
After recruitment, patients should be assessed for EN initiation during first 24 hours after ICU admission. 80% of energy target should be reached within 72 hours.
Attendings decide when and how EN should be administered according to guidelines from academic organizations, such as ESPEN or ASPEN.
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Shanghai, China
Incidence rate of hospital-acquired infections
Hospital-acquired infections include ventilator-associated pneumonia, bloodstream infection, and urinary catheter-associated infection
Time frame: 28 days after ICU admission
mortality of 28 days
Time frame: 28 days after ICU admission
ICU stay
Time frame: from ICU admission to timepoint of patient's discharge or death, up to 12 months
free days of mechanical ventilation
Time frame: during whole ICU stay, up to 12 months
rate of reaching 80% of energy target during 72 hours
Time frame: first 72 hours after ICU admission
EN-associated adverse events
Time frame: during whole ICU stay, up to 12 months
rate of parenteral nutrition delivery
Time frame: during whole ICU stay, up to 12 months
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