Changes in the Diameter of Retinal Vessels After Remote Ischemic Conditioning

University of Aarhus20 enrolled

Overview

Remote ischemic conditioning (RIC) is a therapeutic strategy for protecting organs or tissue against the detrimental effects of acute ischemia-reperfusion injury. It remains unknown whether this can be used in retinal vascular occlusive diseases. The purpose of the present study is to examine whether the autoregulation of retinal vessel diameters in normal persons change after remote ischemic conditioning.

Study Type

INTERVENTIONAL

Allocation

Purpose

BASIC_SCIENCE

Masking

NONE

Enrollment

Conditions

Retinal Artery Occlusion Retinal Vein Occlusion

Interventions

Remote ischemic conditioningPROCEDURE

Briefly reversible restricting of blood flow to upper limb in four cycles of 5 minutes of inflation at 200mm Hg followed by 5 minutes of deflation.

Eligibility

Sex: ALLMin age: 20 YearsMax age: 35 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Normal persons Exclusion Criteria: * Present or previous eye disease * Use of medications except anti-conceptive * Epilepsy * Pregnancy or lactation

Outcomes

Primary Outcomes

Diameter change of retinal vessel

Time frame: immediate

Data from ClinicalTrials.gov

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