Advantages of Autologous Platelet-Rich Fibrin Membrane on Growth Factor Levels and Periodontal Healing

Ataturk University26 enrolled

Overview

Platelet rich fibrin is a second generation platelet concentration which contains various growth factors. The aim of this study is to evaluate the clinical and biochemical efficacy of PRF in subjects of chronic periodontitis in the operation of conventional periodontal flap.

PRF was developed in 2001 by Choukroun in France, it was the second generation fibrin adhesive, and was used to accelerate the soft and hard tissue healing. Many studies have shown beneficial effects of PRF on osteoconductive filler material in sinus lift operations, treatment of periodontal sulcus defect and treatment of furcation defects. Also PRF contains many growth factors. PRF accelerates periodontal regeneration through the gradually excreted growth factors and contributes to the bone regeneration. In this study, the investigators evaluated the effect of PRF on growth factors and its contribution to periodontal regeneration in subjects with chronic periodontitis.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

DOUBLE

Enrollment

Conditions

Chronic Periodontitis

Interventions

Platelet rich fibrineDEVICE

Platelet rich fibrin increases the growth factors. So it was applied for treatment of periodontal bone loss.

Open Flap DebridementDEVICE

Only open flap debridement treatment the bone loss limitedly

Eligibility

Sex: ALLHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Patients with CP who had pocket depth ≤ 5 mm and at least two area (grouped as Control and PRF) with horizontal bone loss after initial treatment Exclusion Criteria: * The subjects excluded in the study had history of systemic disease, were smokers, had allergy to any drug, had need for prophylaxis of antibiotic and had taken antibiotics at least 6 months

Outcomes

Primary Outcomes

Level of Growth Factor

Change from baseline growth factors levels of GCF at 6 weeks were measured by periopaper

Time frame: 6 weeks

Secondary Outcomes

Alteration of Clinical Attachment Level

Change from baseline Clinical Attachment Levels at 9 months were measured with periodontal probe.

Time frame: 9 month

Alteration of Periodontal Pocket Depth

Change from baseline Pocket Depth at 9 months were measured with periodontal probe.

Time frame: 9 month

Data from ClinicalTrials.gov

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