Impact of 30 mg/kg Amikacin and 8 mg/kg Gentamicin on Serum Concentrations in Critically Ill Patients With Severe Sepsis

Centre Hospitalier Universitaire de Nīmes63 enrolled

Overview

Low first-dose peak serum concentrations of amikacin and gentamicin are commonly reported in ICU patients. The present study aimed to assess whether 30 mg/kg amikacin or 8 mg/kg gentamicin achieved target concentrations in ICU patients with severe sepsis.

Study Type

INTERVENTIONAL

Allocation

Purpose

TREATMENT

Masking

NONE

Enrollment

Conditions

Sepsis

Interventions

30 mg/kg amikacin or 8 mg/kg gentamicinDRUG

In order to improve the achievement of target peak concentrations, either 30 mg/kg amikacin or 8 mg/kg gentamicin was prescribed in ICU patients with severe sepsis. In combination with broad-spectrum antibiotics, according to the suspected pathogens and local clinical practice, 30 mg/kg amikacin or 8 mg/kg gentamicin was given (30 min intravenous infusion; the dosage ampoule was systematically emptied with a 5 ml flush). The peak serum concentration sampling occurred 30 minutes after the end of the infusion.

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * ICU patient with severe sepsis * Treated with aminoglycosides Exclusion Criteria: * Renal replacement therapy * Allergy to aminoglycosides * Confirmed and/or suspected to have myasthenia * ICU-acquired neuromuscular disorder * Under guardianship * Prisoners * The patient has already participated in the present protocol

Outcomes

Primary Outcomes

Presence/absence of target peak serum concentration of aminosides

Achievement of targeted peak serum concentration?

Time frame: 30 minutes after the end of the infusion.

Data from ClinicalTrials.gov

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