Effectiveness of Intravenous Immunoglobulins (IVIG) in Toxic Shock Syndromes in Children

Inclusion Criteria: * Child/adolescent: 1 month \< Age \< 17 year-old, * admitted to PICU with a strong suspicion of staphylococcal or streptococcal infection; at least one following criterion, with at least one following criteria: 1. Toxic Shock Syndrom as defined by Centre for Disease Control criteria 2. or group A Streptococcus necrotizing fasciitis (positive streptest) 3. or varicella with infected lesions and rash or positive streptest 4. or erythrodermic rash in menstrual period 5. or pleuropneumonia with erythrodermic rash or positive streptest in pleural fluid 6. or erythrodermic rash and biological fluid positive to streptococcus A or staphylococcus (articular, pericardial, bronchopulmonary, pharynx) * With shock resistant to fluid resuscitation, defined as existence, despite 40 ml/kg of fluid bolus within 1 hour, of: 1. hypotension (\< 5th percentile) 2. or systolic blood pressure \< 2 SD regarding age 3. or need for vasoactive drugs in order to maintain blood pressure at a normal level (dopamine \> 5µg/kg/min or dobutamine, adrenaline, noradrenaline, milrinone whatever the dose) 4. or 2 signs of hypo perfusion among: 1. metabolic acidosis with base deficit \> 5 2. lactate x 2 normal laboratory value 3. diuresis \< 0,5 ml/kg/h 4. capillary refill time \> 5 sec 5. Skin/central temperature difference \> 3°C * With informed consent signed by at least one parent before any procedures or treatments related to the study. Exclusion Criteria: * First signs of shock appeared more than 24h ago * Known hypersensitivity to one of the components (study treatment or placebo , see below) * Hypersensitivity to homologous immunoglobulins, specifically in very rare cases of Ig A deficit, when the patient has anti-IgA antibodies * Known hyperprolinemia * Immunodeficiency (acquired or not), * Immunosuppressive drugs * No health cover