Efficacy of Omega-3 as Adjunctive Therapy for Medically Intractable Epilepsy: A Prospective Open-label Pilot Study

Inclusion Criteria: * Patients with medically intractable, focal or generalized, epilepsy: Patients with localization-related partial onset or generalized tonic/clonic seizure according to the International League Against Epilepsy (ILAE) can be included. Medically intractable epilepsy means that recurrent seizures occur even though two or more anti-epileptic drugs have been used appropriately for over one year. * Seizure frequency criteria: three seizures per one month for recent 3 months before enrollment * Seizure criteria: simple partial, complex partial, or tonic-clonic seizures * Subjects with normal cognitive function: patients who can perform normal daily life. If not definite, enrollment will be done with K-MMSE score over 27. Exclusion Criteria: * Poor general medical condition: comorbid with heart, lung, liver diseases * Patients who have history of pseudo-seizure * Anti-epileptic drugs has been changed in recent one month. * Chronic alcoholic * Seizure count cannot be done since seizures occur successively. * Allergy to fish * High risk of bleeding such as trauma or operation * Liver function abnormality * Pregnant or lactating women, or women who plans to have children * Patients who have participated in the other clinical trial in recent one month