The present study will recruit 9 newly diagnosed type 2 diabetic patient to receive sitagliptin 100mg daily for 12 weeks. The aim of this study was to investigate the composition of gut microbiota before and after the therapy of sitagliptin.
The present study will included 9 newly diagnosed type 2 diabetic patient to receive sitagliptin 100mg daily for 12 weeks. These patients will receive 75g oral glucose tolerance test and fasting plasma glucose levels, lipids levels, fasting insulin levels and 2 hour post-load plasma glucose levels will be measured. Stool samples will be collected before the initiation of the use of sitagliptin. After 12 weeks, all patients will have fasting plasma glucose levels, lipids levels, fasting insulin levels tested. Stool samples will be collected again.
Study Type
INTERVENTIONAL
Allocation
NA
Masking
NONE
Enrollment
9
All the patients will receive sitagliptin 100mg daily
The changes of the composition of gut microbiota before and after the use of sitagliptin
Time frame: 12 weeks
Changes of HbA1c levels
Time frame: 12 weeks
Changes of fasting plasma glucose levels, lipids levels and insulin sensitivity
Time frame: 12 weeks
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