Clinical and experimental data suggest that neutrophil activation and extravasation are deleterious in acute ischemic stroke (AIS) involving an increased risk of unfavorable outcome and hemorrhagic transformation (HT). However, clinical trials targeting neutrophil recruitment in AIS patients were negative. Recently, an experimental study has shown that neutrophil activation and transmigration begin immediately after the occlusion. Inhibition of neutrophil recruitment several hours after the start of ischemia appears therefore too late to have a clinical relevance. The objective is to study the time dependent impact of neutrophils in AIS and the predominant mediators in each time point to identify the appropriate therapeutic target and time window.
Study Type
OBSERVATIONAL
Enrollment
440
Fondation Ophtalmologique Adolphe de Rothschild
Paris, France
neutrophil counts
Plasma neutrophil activation bio-markers
Time frame: before recanalization
neutrophil counts
Plasma neutrophil activation bio-markers
Time frame: immediately after recanalization
neutrophil counts
Plasma neutrophil activation bio-markers
Time frame: 24 hours after recanalization
neutrophil protease counts
Time frame: before recanalization
recanalization score
Thrombolysis in Cerebral Infarction classification (TICI)
Time frame: immediately after endovascular procedure
acute ischemic stroke etiology
as defined by the Trial of Danaparoid (ORG10172) in Acute Stroke Treatment (TOAST classification)
Time frame: within 24 hours after endovascular procedure
severity of neurologic symptoms
National Institutes of Health Stroke Scale (NIHSS)
Time frame: baseline
disruption of the blood-brain-barrier
diagnosis on cerebral Computerized Tomography
Time frame: within 24 hours after endovascular procedure
brain haemorrhage
National Institutes of Health Stroke Scale (NIHSS)
Time frame: 24 hours after endovascular procedure
Recovery of motor function after stroke
modified Rankin scale
Time frame: 3 months
mortality
Time frame: 3 months
adhesion molecules counts
Time frame: before recanalization
adhesion molecules counts
Time frame: immediately after recanalization
adhesion molecules counts
Time frame: 24 hours after recanalization
free plasma DNA counts
Time frame: before recanalization
free plasma DNA counts
Time frame: immediately after recanalization
free plasma DNA counts
Time frame: 24 hours after recanalization
neutrophil protease counts
Time frame: immediately after recanalization
neutrophil protease counts
Time frame: 24 hours after recanalization
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