The main aim and objective of this study was to evaluate the effects of Non- surgical periodontal therapy on the subgingival microbiota and biochemical parameters in patients with chronic kidney disease and chronic periodontitis.
The study was designed as a Non randomized prospective, interventional clinical trial. The sample size for the study was 40 individuals aged between 35-75 years, equally divided into two groups. Group I--- Patients with Chronic kidney disease and chronic periodontitis (Test) Group II--- Patients with Chronic periodontitis only (Controls) At baseline both the groups were analyzed for clinical, microbiological and also biochemical parameters and underwent Non-surgical Periodontal treatment (i.e. scaling and root planning). All parameters were reassessed again after 3 months. A total of 20 patients attending the outpatient wing of Hyderabad Kidney Centre , Malakpet,Hyderabad who were diagnosed clinically with Chronic Kidney disease and willing to participate in the study were included in the study. Another 20 patients attending the outpatient wing of Department of periodontics, Panineeya Mahavidyalaya Institute of Dental Sciences \& Hospital, Hyderabad, diagnosed with Chronic Periodontitis and willing to participate in the study were taken. Biochemical parameters considered included -serum creatin \& urinary albumin: creatin ratio. Microbiological assay was done by Polymerase chain reaction test (PCR) i.e., pooled plaque samples were taken from both predialysis as well as chronic periodontitis patients.
Study Type
INTERVENTIONAL
Allocation
NON_RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
40
All the patients were asked to use a preprocedural mouthrinse and scaling and rootplaning was done using ultrasonic scalers.
Levels of Microbiological and Biochemical Parameters
Microbiological assay was done by PCR test i.e., pooled plaque samples were taken from both predialysis as well as chronic periodontitis patients at baseline and 3 months after scaling and root planing. Supragingival plaque was removed carefully with a sterile scaler to prevent the contamination of the samples.Sample was harvested from the same site with a sterile Gracey curet 5-6 with one single vertical stroke on the root surface. Biochemical assay was done by Modified Jaffe's reaction to assess the levels of Serum Creatinine and urine samples were taken to assess the Albumin:Creatinine ratio
Time frame: Change in levels of Microbiological and Biochemical parameters were assessed at baseline and 3 months after scaling and rootplaning
Clinical parameter -Gingival Index (GI)
The Gingival index was assessed using a University of Carolina-15 (UNC-15) Probe.
Time frame: Change in the GI was assessed at baseline and 3 months after Scaling and rootplaning
Clinical Parameters-Probing depth(PD) and Clinical attachment levels (CAL)
The Pd was assessed using UNC-15 Probe
Time frame: Change in Pd was assessed at baseline and 3 months after scaling and rootplaning
Clinical Parameter- Clinical attachment levels(CAL)
The CAL was assessed using UNC-15 Probe
Time frame: Change in CAL was assessed at baseline and 3 months after scaling and rootplaning
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.