The objective is to investigate neuro-anatomical correlates of gastrointestinal taste stimulation by means of functional MRI before and after bariatric surgery. Intragastric administration of glucose, monosodium glutamate, chloroquine and placebo is followed by functional brain MRI in obese humans before and 3 months after surgery.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
TRIPLE
Enrollment
16
Tap water 200ml
25g Glucose in 200ml tap water
1g monosodium glutamate in 200ml tap water
University Hopital Basel
Basel, Switzerland
RECRUITINGEffect of tastants on cerebral blood flow measured by functional brain MRI
Time frame: changes from baseline to one hour after treatment
Effect of tastants plasma glucagon-like peptide (GLP-1) concentrations
Time frame: changes from baseline to one hour after treatment
Effect of tastants plasma ghrelin concentrations
Time frame: changes from baseline to one hour after treatment
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17mg quinine in 200ml tap water