Glucose and Fructose Stimulated Brain Activity in Obese Subjects Before and After Bariatric Surgery

University Hospital, Basel, Switzerland15 enrolled

Overview

The objective is to investigate neuro-anatomical correlates of the regulation of energy intake by means of functional MRI before and after bariatric surgery. Administration of glucose as well as fructose is followed by functional brain MRI, and findings are correlated with serum glucagon-like peptide 1 (GLP-1) levels as an endogenous satiety signal in obese humans.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

TRIPLE

Enrollment

Conditions

Exploratory Behavior

Interventions

Tap waterDIETARY_SUPPLEMENT

300ml tap water via nasogastric tube

GlucoseDIETARY_SUPPLEMENT

300ml tap water with 75g glucose via nasogastric tube

FructoseDIETARY_SUPPLEMENT

300ml tap water with 25g fructose via nasogastric tube

Eligibility

Sex: ALLMin age: 18 YearsMax age: 55 Years

Medical Language ↔ Plain English

Inclusion Criteria: * right-handed * morbidly obese patients * scheduled for bariatric surgery Exclusion Criteria: * Diabetes mellitus * cardiovascular disease * neurologic or psychiatric disorder

Locations (1)

University Hospital Basel

Basel, Switzerland

Outcomes

Primary Outcomes

Functional magnetic resonance imaging (fMRI) in healthy, obese volunteers while they performed a working memory task: changes in cerebral blood flow

Time frame: changes from baseline to one hour after treatment

Secondary Outcomes

Changes in plasma glucose

Time frame: Changes from baseline to one hour after treatment

Changes in plasma insulin

Time frame: Changes from baseline to one hour after treatment

Changes in Plasma GLP-1

Time frame: Changes from baseline to one hour after treatment

Data from ClinicalTrials.gov

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