Eighty community-living individuals in Uppsala municipality will be included. Intervention: Outdoor walking exercise program and one strength exercise. Methods: Clinical assessments, questionnaires and medical records. Assessment of motor function, cognition, level of physical activity, food intake and perceived stress are performed at screening as baseline measurements. Walking capacity, mobility, handgrip strength, body composition and cardiovascular risk markers will be assessed at baseline and after 12 week of training. At one year after training health-related quality of life, another cardiovascular incidence and mortality will be documented.
Eighty community-living individuals in Uppsala municipality will be included in a randomized controlled trial with two arms. Intervention: Participants will perform an outdoor walking exercise program together with one strength exercise for 12 weeks. The intensity and frequency of the training will progressively increase. Participants are supposed to walk and perform strength training 5-7 days/week. Methods: Clinical assessments, questionnaires and medical records used for documentation of age, sex, comorbidity, blood pressure, medications and previous education. Assessment of motor function, cognition, level of physical activity, food intake and perceived stress are performed at screening as baseline measurements. Walking capacity (primary outcome measure), mobility, handgrip strength, body composition and cardiovascular risk markers will be assessed at baseline and after 12 week of training. At one year after training health-related quality of life, another cardiovascular incidence and mortality will be evaluated. Power analysis is performed. The investigators will analyze the data using an intention-to -treat analysis. Participants should have participated in at least 50% of the training sessions
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Enrollment
80
Exercise group: Participants are supposed to perform an outdoor walking exercise program and one strength exercise for 12 weeks. The first 2 weeks start with daily walks. The intensity and frequency of walks will progressively increase performed according to the Borg scale: 12-15, ie, moderate to strenuous. Participants will walk 5-7 days/week. Added to this is a strength exercise, i.e. chair-rising which also should be performed daily.
Control-Group: Treatment as usual for 12 weeks, without restriction of being physically active.
Birgit Vahlberg
Uppsala, Sweden
RECRUITING6 minute walk test (6MWT)
walking capacity
Time frame: from baseline walking capacity to three months
Short Physical Performance Battery (SPPB)
mobility
Time frame: from baseline SPPB to three months
10 meter walk test (10mWT)
gait speed
Time frame: from baseline 10mWT to three months
Hand-dynamometer (Jamar)
hand-grip strength
Time frame: from baseline Jamar to three months
Body composition (bioelectric impedance analysis)
muscles and fat mass and BMI
Time frame: from baseline body composition to three months
Cardiometabolic risk markers
blood lipids, c-reactive proteins (CRP), blood glukos, HbA1c, Insulin-like growth factor (IGF-1), Interleukin-6 (Il-6)
Time frame: from baseline cardiometabolic risk markers to three months
Heart and lung foundation stress test
self-perceived stress
Time frame: at baseline
Food frequency questionnaire
self-reported food intake and quality
Time frame: at baseline
Montreal outcome assessment (MoCA)
cognition
Time frame: at baseline
Modified rankin scale (MRS)
motor function
Time frame: at baseline
Mortality
register-based mortality
Time frame: from baseline to 1 year
Health-related quality of life
register-based quality of life
Time frame: from baseline to 1 year
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.