Trial in Patients With Psoriasis Treated With Methotrexate Using an Optimized Treatment Schedule (METOP)

Inclusion Criteria: 1. Are 18 years of age or older at time of informed consent; may be men or women. 2. Are MTX naïve 3. Moderate to severe plaques psoriasis (according rule of ten (PASI ≥10 or BSA ≥ 10 or DLQI ≥ 10) for at least 6 months with or without psoriatic arthritis (however, highly active psoriatic arthritis is excluded, defined by. \> 5 swollen tender joints or soles and C-Reactive Protein (CRP) \>2 x UNL) . 4. Women of childbearing potential and all men must be using a highly effective method of contraception (pearl index \< 1%) as defined blow and must agree to continue to use such measures and not become pregnant or plan a pregnancy until 6 months after receiving the last injection of Investigational Medicinal Product (IMP).Highly effective method is defined as: Use of oral, injected or implanted hormonal methods, intrauterine device (IUD) or intrauterine system (IUS), barrier methods of contraception: condom or occlusive cap (diaphragm or cervical/vault caps) with spermicidal foam/gel/film/cream/suppository. 5. Able to adhere to the study visit schedule and other protocol requirements. 6. Capable of giving informed consent. The informed consent must be obtained prior to any study related procedures. 7. Must avoid prolonged sun exposure and avoid use of tanning booths or other ultraviolet light sources during study. 8. Must agree not to receive a live virus or live bacterial vaccination 4 weeks prior to the first IMP s.c. administration, during the trial and up to 3 months after the last injection. 9. Chest X-ray investigation within the last 6 months prior to first s.c. administration of IMP and show no clinically relevant abnormalities Exclusion Criteria: 1. Currently have non-plaque forms of psoriasis (eg, erythrodermic, guttate, or pustular). 2. Have current drug-induced psoriasis (eg, a new onset of psoriasis or an exacerbation of psoriasis from beta blockers, (hydroxy-) chloroquine, or lithium). 3. Are pregnant, nursing, or planning pregnancy (both men and women) while enrolled in the study. 4. Have screening laboratory test results for the following parameters outside the stated ranges (please refer also to : 1. Hemoglobin \< 10 g/dL 2. White blood cells \< 3.0 x 109/L 3. Neutrophils \< 1.5 x 109/L 4. Platelets \< 100 x 109/L 5. Creatinine clearance (calculated according to Cockcroft-Gault) \< 50 mL/min) 6. Aspartate Aminotransferase (AST), Alanine Aminotransferase (ALT), and Gamma Glutamyltransferase (γ-GT) levels must be \> 2 times the upper limit of normal range 7. Bilirubin \> 5mg/dl (85,5 μmol/l) 8. Hypalbuminemia \<3,5 g/dl 5. Have used any other IMP within the previous 4 weeks or 5 times the half-life of an investigational agent prior to the first s.c. administration of the IMP of this study, whichever is longer. 6. Not able or willing to wash out any prohibited medications as listed below. * Any biologics; washout 5 times of half-life * Phototherapy or any systemic medications that could affect the psoriasis (including but not limited to oral or injectable corticosteroids, retinoids, 1,25 dihydroxy vitamin D3 and analogues, sulfasalazine, hydroxyurea, or fumaric acid derivates), within 4 weeks * Any topical medications that could affect the psoriasis (e.g. corticosteroids, anthralin, calcipotriene, topical vitamin D derivates, retinoids, tazarotene), within 2 weeks * Any systemic immunosuppressants (e.g. azathioprine, cyclosporine, 6-thioguanine, mercaptopurine, mycophenolate mofetil, hydroxyurea, and tacrolimus) ,within 4 weeks * lithium, antimalarial agents To be stopped directly prior to first s.c. administration of IMP * Intramuscular gold ,Within 4 weeks Patients who take prohibited medications that cannot be washed out within 4 weeks or at least 5 times of the half-life of the investigational agent prior to first s.c. administration of IMP should not be asked to participate in the trial. 7. Have a history of chronic or recurrent infectious disease or had a serious infection or have been hospitalized or received i.v. antibiotics for the treatment of an infection within 2 months prior to screening. 8. History of radiotherapy or planed concomitant radiotherapy 9. Ulcers of the oral cavity (e.g. ulcerative stomatitis) and/or known gastrointestinal ulcer disease 10. A known B12/cobalamin deficiency 11. Known diagnosed ascites or pleural effusions 12. Have a history of latent or active Tuberculosis (TB) (prior to screening). 13. Have current signs or symptoms of severe, progressive, or uncontrolled renal (specifically with calculated creatinine clearance \< 20), hepatic (especially with bilirubin \> 5mg/dl (85,5 mol/l), hematological, gastrointestinal, endocrine, pulmonary, cardiac, neurologic, cerebral, or psychiatric disease. 14. Have any known malignancy or have a history of malignancy (with the exception of basal cell carcinoma, squamous cell carcinoma in situ of the skin, or cervical carcinoma in situ that has been treated with no evidence of recurrence, or squamous cell carcinoma of the skin that has been treated with no evidence of recurrence within 5 years prior to the first administration of study agent). 15. Have shown a previous immediate hypersensitivity response, including anaphylaxis, to the folic acid 16. Are unable or unwilling to undergo multiple venipunctures because of poor tolerability or lack of easy access to veins. 17. Are known to have had a substance abuse (drug or alcohol) problem within the previous 12 months. 18. Staff or relatives/partner of any clinical research site