Gestational Diabetes Mellitus, Obesity and Periodontal Disease

University of Sao Paulo67 enrolled

Overview

This study evaluated the periodontal condition of gestational diabetes mellitus (GDM) patients and a healthy non-pregnant control group. For the GDM group all medical data were recorded, including obesity/insulin resistance indicators.

Gestational diabetes mellitus is associated to a worse periodontal condition. Many patients with these two diseases are also obese. After delivery, some patients maintain the pre-pregnancy obesity status and this condition is also associated to periodontal disease. The mechanisms involved in the relationship of all these medical and periodontal conditions are not clear.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Diabetes Mellitus, Gestational Periodontal Diseases Obesity

Interventions

Gestational diabetes mellitusOTHER

Eligibility

Sex: FEMALEMin age: 18 YearsMax age: 42 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Inclusion criteria for GDM group was pregnant women with diagnosis of GDM based on glucose determination described in a previous study (19) and under medical treatment of an endocrinologist and the presence of at least one tooth per sextant. * Inclusion criteria for control group were absence of periodontal disease, mean age similar to test group and presence of at least one tooth per sextant. Exclusion Criteria: * The exclusion criteria for GDM group were pregnant women without diagnosis of diabetes, age below 18 years or higher than 42 years, and the presence of other systemic diseases. * In control group, women were excluded if they were pregnant, had diabetes or other systemic disease and age below 18 years or higher than 42 years.

Locations (1)

Bauru School of Dentistry

Bauru, São Paulo, Brazil

Outcomes

Primary Outcomes

Periodontal disease (gingivitis and periodontitis) measured by a periodontal probe and classified according to severity

Severe periodontitis was defined by the presence of ≥ 2 interproximal sites in different teeth with CAL ≥ 6mm and ≥1 interproximal site with PPD ≥5mm. Moderate periodontitis was defined by the presence of ≥ 2 interproximal sites in different teeth with CAL ≥ 4mm or ≥ 2 interproximal sites in different teeth with PPD ≥5mm. Mild periodontitis was defined as ≥ 2 interproximal sites in different teeth with ≥ 3 mm CAL and ≥ 2 interproximal sites in different teeth with ≥ 4 mm PPD or at least 1 site with PPD ≥ 5 mm (20,21). Gingivitis was determined as follows: Subjects were considered healthy if presented PPD ≤3mm/BOP extent scores \< 10% and with gingivitis if presented PPD ≤3mm/ BOP extent scores \>10%. Prevalence of periodontal disease was the sum of gingivitis, mild, moderate and severe periodontitis.

Time frame: One day

Obesity measured by a tape and a scale

Obese if: body mass index - BMI ≥ 25 Kg/m2 (weight in kilograms, height in meters) Obese if : waist-to-hip ratio - WHR \>0.85 (cm)

Time frame: one day

Gestational diabetes mellitus diagnosed by an endocrinologist

Diagnosis stablished by a doctor based on glucose determination. The data was registered in the patient's medical chart.

Time frame: one day

Secondary Outcomes

Dyslipidemia as an indicator of obesity/insulin resistance

The data was registered in the patient's medical chart. Dyslipidemia = HDL ≤ 35 mg/dL / LDL≥ 100 mg/dL / Total cholesterol ≥200 mg/dL / Triglycerides ≥ 150 mg/dL / VLDL \< 30 mg/dL

Time frame: one day

Leukocytosis as an indicator of inflammation

The data was registered in the patient's medical chart. ≥ 10.000/L

Time frame: one day

Data from ClinicalTrials.gov

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