Efficacy Study of Acetazolamide Versus Diazepam in Continuous Spike and Wave/Landau-Kleffner Syndrome

Inclusion Criteria: * ESES and clinical CSWS/LKS defined by all of the following: * SWI ≥50% during first hour of sleep * Bilateral synchrony of discharges during sleep * Clinical evidence of behavior and/or academic regression * Daytime SWI ≤20% Exclusion Criteria: * Previous treatment with benzodiazepine or acetazolamide for Electrical Status Epilepticus in Sleep (ESES) * Current treatment with carbamazepine, phenytoin, oxcarbazepine, phenobarbital, vigabatrin or lamotrigine * Antiepileptic medication changes over the month prior to enrollment * Epileptic encephalopathy other than CSWS/LKS * Prior serious adverse reaction to benzodiazepines or acetazolamide * Sulfa allergy * Progressive underlying neurologic condition * Frequent seizures that would prevent the patient from maintaining a stable dose of medications * Female patient that has begun menses or is pregnant