Conventional Microneedling vs Microneedling With 5-FU (MMP) for Idiopathic Guttate Hypomelanosis (IGH) Repigmentation

Inclusion Criteria: * Healthy males and females, between ages 30 and 70 * Photodamaged skin on upper limbs with IGH lesions meeting aforementioned criteria and excluding differential diagnosis * Fitzpatrick skin types III - V * Apt and willing to comply with the entire program as well as appointments, treatment and examination * Capable of understanding and providing a written informed consent * Fertile women will have to use a viable birth control method for at least 3 months prior to entry and throughout the entire study Exclusion Criteria: * Pregnancy, intention to become pregnant during the course of the study, less than 3 months after delivery or less than 6 weeks after breastfeeding cessation. * Uncontrolled comorbidity or any disease that, in the investigator's opinion, may interfere with the treatment, healing or cure. * Present symptoms of hormonal disturbances, as per the investigator's criteria. * Constitutional photosensitivity or due to metabolic disfunction, or due to use of external agentes (pharmaco, natural products, etc.) prior to initial treatment or during the study. * Use of oral isotretinoin 6 months prior to initial treatment or during the course of the study. * Prior treatment in target área 3 months prior to initial treatment or during the course of the study. * Adverse reaction to any external agentes (gel, lotions or anesthetic creams) required during the study in case no alternative is available for such agent. * History of keloids or other type of hypertrophic scar formation or poor wound healing in a previously injured area of skin. * History of collagen disease. * Displastic nevus or suspicious carcinogenic lesion in área to be treated. * Hemmorragic disorder or under anticoagulant medication, including the use of aspirin not permitting a minimum 10-day suspension prior to each treatment period (in accordance with the criteria of the patient's physician). * Skin frailty of sensitivity, favoring hemmorrage. * History of immunosuppresion / immunological deficiency disorders (including HIV infection) or use of immunosuppressant medication. * Participation in a study involving medication or another device three months prior to the study or during enrollment herein. * Any condition which, in the investigator's opinion, would jeopardize the study or its participants, such as acute psychiatric disorders, panic syndrome or any aversion to needles or to the procedure. * Hypochromiant dermatoses such as vitiligo, pitiriasis, versicolor, albinism. * Dermatoses that evolve like Koebner's phenomenon. * Cutaneous infectious process at the application site.