Relationship Between Gestational Diabetes Mellitus and Inflammatory Adipocytokins in Obese Mothers and Their Newborn at Delivery

Centre Hospitalier Universitaire de la Réunion40 enrolled

Overview

ADIPOGEST study aims at comparing circulating levels of inflammatory adipocytokins and C-reactive protein in obese women and their newborn at delivery whether exposed or not to Gestational Diabetes Mellitus (GDM)

ADIPOGEST is a cross sectional study in which mothers are divided into 2 groups : exposed and unexposed to GDM, matched on pregestational BMI, date of delivery and child gender. Mothers are recruited in the maternity ward of the University Hospital in South of Reunion Island. It is planned a conveniance sample of 20 mother-child pairs per group.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Diabetes, Gestational

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Pregnant women * Obese women (BMI : 30 kg/m² or more) * Aged over 18 years * With single pregnancy * With alive newborn at 37 weeks of amenorrhea or more * With informed consent Exclusion Criteria: * Smoker * Treatments by corticoïds or thyroid hormons * Overt diabetes * Complicated pregnancy * Premature delivery threat

Locations (1)

Centre Universitaire de La Réunion

Saint-Pierre, France

RECRUITING

Outcomes

Primary Outcomes

Blood levels of leptin in mother and her child

Time frame: 2 years

Blood levels of adiponectin in mother and her child

Time frame: 2 years

Blood levels of IL-6 in mother and her child

Time frame: 2 years

Blood levels of TNF-alpha in mother and her child

Time frame: 2 years

Blood levels of C- Reactive Protein in mother and her child

Time frame: 2 years

Secondary Outcomes

Blood level of C-peptide in mother

Time frame: 2 years

Data from ClinicalTrials.gov

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