The purpose of this study is to determine whether the vaginal estriol before vaginal surgery for pelvic statics disorders is more efficacy of no estriol treatment on vaginal health and quality of life.
The aim of this randomized study was to evaluate the efficacy of low concentration of vaginal estriol gel (0.005%, 50 micrograms/1 g vaginal gel) in women with pelvic statics disorders before vaginal surgical treatment (group A), assessing the vaginal dryness, dysuria, vaginal maturation index (VMI), pH and the Vaginal Health Index (VHI). Secondary, to investigate the changes of sexual function and QoL. Women without pre surgical estriol treatment constituted the control group (group B).
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
88
Study Group, treated with estriol Control Group, no drug treatment Both groups will undergo vaginal surgery for prolapse
Control Group
Vaginal Health Indexes
Time frame: vaginal gel containing 50 µg of estriol, daily, for a complete cycle of treatment of 12 weeks
QoL and sexual function were investigated by the Short Form 36 (SF-36)
Time frame: vaginal gel containing 50 µg of estriol, daily, for a complete cycle of treatment of 12 weeks
Pelvic Organ Prolapse/Urinary Incontinence Sexual Questionnaire short form (PISQ-12), respectively
Time frame: vaginal gel containing 50 µg of estriol, daily, for a complete cycle of treatment of 12 weeks
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