Therapeutic plasma exchange (TPE) should used for patients with septic shock in a controlled, prospective study focusing on the organ functions of the patients.
Therapeutic plasma exchange (TPE) should used for patients with septic shock in a controlled, prospective study. Investigators will study three groups: 1. untreated control group; 2. TPE group, plasma separation carried out by filtration; 3. TPE group, plasma separation carried out by centrifugation. All treated patients should treated two (minimal) to five times by TPE, depending on the need of norephinephrine for the therapy. For each session 40 ml/kg body weight plasma should be exchange. Fluid resuscitation will be done with fresh frozen plasma. The study will focusing on the organ functions of the patients, especially liver-, kidney- and nervous function and also displayed in the SOFA score on study days 3 and 7.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Enrollment
30
All treated patients should treated two (minimal) to five times by TPE, depending on the need of norephinephrine for the therapy. For each session 40 ml/kg body weight plasma should be exchange. Fluid resuscitation will be done with fresh frozen plasma.
Intensive Care Units PIT 1+2, University Hospital Rostock
Rostock, Germany
RECRUITINGSOFA score ≥ 2 Punkte
SOFA: Sepsis-related Organ Failure Assessment score
Time frame: day 3
SOFA score ≥ 2 Punkte
SOFA: Sepsis-related Organ Failure Assessment score
Time frame: day 7
28-day survival
Observation time 28 days
Time frame: day 28
Hospital survival
Leave the patients the hospital?
Time frame: 1 year
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