A Study in Healthy Volunteers and Patients With Chronic Hepatitis B

Healthy volunteers: 1. Male or female between 18 and 65 years old with a BMI of 18-32kg/m2 2. Must be in good health and not have any health condition which could interfere with the absorption, distribution or elimination of study drug, or with the clinical and laboratory assessments in this study CHB patients: 1. Male or female between 18 and 65 years of age, with a BMI of 18-35kg/m2 and a minimum body weight of 45 kg 2. Must have chronic hepatitis B with no history of clinical decompensation 3. Seropositive for HIV, HCV, or HDV antibody at Screen 4. Previous treatment with any HBV antiviral treatments within the last 3 months 5. Other known cause of liver disease, including NASH