Sertraline in Addition to Standard of Care Treatment for Coccidioidomycosis

Inclusion Criteria: * Severe coccidioidomycosis infection, manifest as by one of: * Coccidioidal meningitis; * Severe pulmonary infection requiring intensive care unit level of care; * Disseminated infection (in clinical opinion of the investigator); or * Clinical progression after \>2 months of high dose fluconazole. * Laboratory confirmation of Coccidioides infection by culture, histopathology, coccidioides polymerase chain reaction, positive complement fixation titer, or Coccidioides antigen Exclusion Criteria: * Age \< 18 years * Cannot or unlikely to attend regular clinic visits * Presence of jaundice or known liver cirrhosis * Pregnancy * If there is a concern of pregnancy, a negative urine (or serum) pregnancy test before study entry is required. * Women of childbearing potential will have pregnancy test at enrollment and will be recommended to use contraception and referred to family planning services as necessary. (Refer to informed consent document.) * Currently breastfeeding * Active drug use (amphetamine or cocaine) or requirement for concomitant medications that raise the risk of serotonin syndrome * Prolonged corrected QT interval or Left Bundle Branch Block on baseline electrocardiogram