Disruption of sleep and alertness is one of the most disabling non-motor symptoms of Parkinson's disease (PD). Mechanisms leading to impaired sleep and alertness in PD are not well understood, and treatment options remain limited. The proposed research will examine markers of the circadian system, sleepiness and sleep quality in PD patients. Further, the project will examine effects of bright light exposure on circadin function, sleep and alertness in PD.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
TRIPLE
Enrollment
65
Massachusetts General Hospital
Boston, Massachusetts, United States
Parkinson's Disease Sleep Scale (PDSS-2) score to measure sleep quality
Time frame: 8 weeks
Epworth Sleepiness Scale (ESS) score to measure daytime sleepiness
Time frame: 8 weeks
Non-Motor Symptoms Assessment Scale for Parkinson's Disease (NMSS) score to measure the severity and frequency of non-motor symptoms
Time frame: 8 weeks
Plasma melatonin levels collected through blood samples to measure melatonin amplitude and circadian regulation
Time frame: 8 weeks
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