This study compares desflurane with sevoflurane for school-age children in postoperative cognitive function.
The postoperative cognitive dysfunction (POCD) of school-age children (6-14 age) after operation draw more attention from both society and family. It is well known that, compare with sevoflurane, desflurane could improve cognitive function in elderly patients. But whether Desflurane could improve postoperative cognitive function compare with Sevoflurane for the school-age children, there is no consistent conclusion.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
HEALTH_SERVICES_RESEARCH
Masking
QUADRUPLE
Enrollment
600
Anesthesia maintenance: After endotracheal intubation, half of the patients will be randomized into Desflurane Group. The gas flow rate of Desflurane group is 2 L/min, include 50％ O2 and 4～5％ Desflurane.
Anesthesia maintenance: After endotracheal intubation, half of the patients will be randomized into Sevoflurane Group. The gas flow rate of Desflurane group is 2 L/min, 50％O2 and 1.7-2.0% Sevoflurane.
The incidence of postoperative cognitive dysfunction
Cognitive function score should be carried out for all children at preoperative 1d, postoperative 2 d, 3d and 7d. If postoperative score compared with preoperative score drop 1 points or more, then postoperative cognitive dysfunction will be recorded.
Time frame: Within 7 days after operation
age
years old
Time frame: 1 day before operation
male
If the child is boy,it's "yes",or it's "no".
Time frame: 1 day before operation
height
CM
Time frame: 1 day before operation
weight
kg
Time frame: preoperation
previous operation history
If the child had previous operation history,it's "yes",or it's "no".
Time frame: preoperation
the duration of anesthesia
minutes
Time frame: From the time began to give the anesthetic to the time of pull out the endotracheal intubation
the duration of operation
minutes
Time frame: Surgery end time minus the start time
total blood loss
ml
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Time frame: The total blood loss of the whole surgery time.
total volume of infusion
ml
Time frame: The total volume of infusion of the whole surgery time.
whether there is respiratory depression in postanesthesia care unit
If the child has respiratory depression during this time,it's "yes",or it's "no".
Time frame: The period which the patient stay at post anesthesia care unit,from the time enter to postanesthesia care unit to the time leave postanesthesia care unit,the estimated period is up to 30 minutes.
the length of hospital stay
days
Time frame: the time from admission to hospital to discharge from hospital,the estimated period is up to 5 days.
S100β
obtain the children's plasma to detection S100β with ELEASE.
Time frame: 1 day after surgery
NSE
obtain the children's plasma to detection NSE with ELEASE.
Time frame: 1 day after surgery