Cardiac Safety of Dihydroartemisinin-Piperaquine Amongst Pregnant Women in Tanzania

Inclusion Criteria: 1. Participant presents for antenatal care at the district hospital. 2. Participant is between 18 years and 34 years of age. 3. Participant currently lives within the pre-defined catchment area of the district hospital. 4. Participant will remain within the same area through to the post-partum visit. 5. Participant agrees to deliver her child at the district hospital. 6. Participant agrees to a post-partum visit at her residence or at the district hospital. 7. Participant has no apparent severe infection or any condition that requires hospitalization. 8. Participant is not currently enrolled in another study. 9. Participant is not known to have heart disease or a known cardiac ailment. 10. Participant reports having taken no medication in the previous 28 days. 11. Participant reports having no known allergy to the study drugs or any sulphonamides. 12. Participant agrees to remain under observation for 3 hours at the district hospital and to abstain from food ingestion during the observation period in keeping with the European Medicines Agency product information for dosing with dihydroartemisinin-piperaquine. 13. Participant is willing to undergo all study procedures including sonography, ECG testing, and to provide blood samples for malaria microscopy and pharmacokinetic analysis. 14. Participant agrees to human immunodeficiency virus (HIV) testing regardless of prior results and no matter how recent. 15. Participant is not severely anaemic (haemoglobin concentration \> 5g/dL). 16. Participant provides written consent. 17. Participant has an axillary temperature \< 37.5 Celsius. 18. Participant is pregnant with a singleton determined by sonography. 19. Participant is between 16 and 35 weeks gestation determined by sonography. Exclusion Criteria: 1. Participant is younger than 18 years of age and older than 35 years of age. 2. Participant does not currently live within the pre-defined catchment area of district hospital. 3. Participant will not remain within the same area through to the post-partum visit. 4. Participant does not agree to deliver her child at the district hospital. 5. Participant does not agree to a post-partum visit at her residence or at the district hospital. 6. Participant has a severe infection or any condition that requires hospitalization. 7. Participant is currently enrolled in another study. 8. Participant is known to have heart disease or known cardiac ailment. 9. Participant reports having taken any medication in the previous 28 days. 10. Participant reports having an allergy to the study drugs or any sulphonamides. 11. Participant does not agree to abstain from food ingestion during the observation period after dosing. 12. Participant does not agree to remain under observation at the district hospital 3 hours after dosing has occurred. 13. Participant does not agree or is unwilling to undergo all study procedures including sonography, ECG testing, and to provide blood samples for malaria microscopy (and treatment group assignment) and pharmacokinetic analysis. 14. Participant does not agree to HIV testing or is diagnosed as HIV-positive during screening, 15. Participant is not severely anaemic (haemoglobin concentration \> 5g/dL). 16. Participant does not provide written consent. 17. Participant has an axillary temperature \> 37.5 Celsius or is symptomatic for malaria. 18. Participant is carrying a multiple pregnancy (e.g. twins). 19. Participant is between \< 16 weeks and \> 36 weeks gestation. 20. Participant has a QTc \> 450 milliseconds. 21. Participant has a heart rate \< 40 beats per minute.