The Effect of Ticagrelor With or Without Atorvastatin on Endothelial Function in Healthy Males

Inclusion Criteria: * Healthy male subjects; 18 - 40 years of age * Body mass index between 18 and 27 kg/m2 * Written informed consent * Normal findings in medical \& bleeding history * Non-smoking Exclusion Criteria: * Regular intake of any medication including OTC drugs and herbals within 2 weeks before IMP administration * Known coagulation disorders (e.g. haemophilia, von Willebrand´s disease) * Known disorders with increased bleeding risk (e.g. peridontosis, haemorrhoids, acute gastritis, peptic ulcer, intestinal ulcer) * Known sensitivity to common causes of bleeding (e.g. nasal) * History of thromboembolism * History of occlusive vascular diseases * History of vascular anomalies * History of hypercholesterolemia * History of myopathy * Impaired liver function (AST, ALT, gGT, bilirubin \> 3 x ULN) * Impaired renal function (serum creatinine \> 1.3 mg/dl) * Elevated creatinine-kinase or serum-myoglobin (\> 3 x ULN) * Any other relevant deviation from the normal range in clinical chemistry, haematology or urine analysis * HIV-1/2-Ab, HbsAg or HCV-Ab positive serology * Systolic blood pressure above 145 mmHg, diastolic blood pressure above 95 mmHg * Known allergy against any test agent under study * Regular daily consumption of more than on litre of xanthine-containing beverages or more than 40g alcohol * Participation in another clinical trial during the preceding 3 weeks