This project will investigate the synergistic effects of Aerobic and Resistance type Exercise, in combination with Protein Supplementation, on; Body Composition, Musculoskeletal Functioning, Nutritional Status and Quality of Life in Age-related Sarcopenia.
Musculoskeletal ageing is an inevitable process associated with profound morphological and functional changes that will ultimately transition an individual from independent, to dependable living, relying heavily on personal health care for survival. The United Kingdom (UK) population aged over 65 years is expected to rise from 8.8 to 11.3 million by 2025. As life expectancy increases due to advances in medical treatment, an age-related disease termed sarcopenia, has become more prevalent in the elderly. Sarcopenia, described as the loss of musculoskeletal mass, strength and/or physical functioning with age, manifests after the 6th decade and rapidly increases after the 8th decade, resulting in a deterioration of health status and quality of life. To manage the looming health and economic consequences of sarcopenia, suitable therapeutic strategies to manage the condition are warranted. Therefore, this randomised control trial (RCT) will investigate the effects of 16-weeks of exercise and nutritional interventions in inactive senior citizens (60 - 90 years old).
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
NONE
Enrollment
110
1.2-1.5g/kg/body weight per day
30-60 minutes per week of moderate intensity exercise
60 minutes per week of progressive resistance training
Liverpool Hope University
Liverpool, Merseyside, United Kingdom
Body Composition: Lean Muscle/Fat Tissue 1) appendicular lean mass (kg) divided by height (meters-squared) and 2) appendicular lean mass divided by body mass index
Time frame: 16 weeks
Grip Strength: Hand Grip Dynanometer (kg)
Time frame: 16 weeks
Gait speed during timed 4-meter walk (m/s)
Time frame: 16 Weeks
Time to complete five chair rises (m/s)
Time frame: 16 Weeks
Balance assessment: 1) feet side to side, 2) semi-tandem, 3) full tandem, and 4) single leg. Scored as Yes or No.
Time frame: 16 Weeks
Isometric Strength - Knee Flexion/Extension: Dynanometer (Nm/Kg)
Time frame: 16 Weeks
Muscle Fatigue: Upper & Lower limb: 25% of MVC during 60 seconds using Electromyography (EMG), measured in millivolts (mV)
Time frame: 16 Weeks
Exercise Tolerance: Six Minute Walk Test (metres)
Time frame: 16 Weeks
10-metre Gait analysis during habitual walking speed using Electromyography (EMG)
Time frame: 16 Weeks
10-metre Gait analysis during habitual walking speed using Three-Dimensional Motion Capture - 1) Spatiotemporal, 2) Kinematics
Time frame: 16 Weeks
Biochemical: Glycated Haemoglobin (HBA1c) (%)
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Time frame: 16 Weeks
Biochemical: C-Reactive Protein (CRP) (mg/L)
Time frame: 16 Weeks
Biochemical: Insulin-Like Growth Factor 1 (IGF-1) (ng/ml)
Time frame: 16 Weeks
Arterial Pressure: Pulse Wave Velocity (m/s)
Time frame: 16 Weeks
Energy Balance: Periodic Food Diary (Kcal)
Time frame: 16 Weeks
World Health Organization Quality Of Life Assessment (WHOQOL): Each question is scored from 1-5 on a response scale
Time frame: 16 Weeks
Short-Form Health Survey (SF-12): Each question is scored between 1-6 on a response scale
Time frame: 16 Weeks
Activities of Daily Living (ADL): Each response is scored as either: 0 or 1
Time frame: 16 Weeks
Mini-Mental State Examination (MMSE): Each correct response is scored as 1 point
Time frame: 16 Weeks
Nutritional Status: Mini-Nutritional Assessment (MNA) - Classified as (Low, Moderate, High risk)
Time frame: 16 weeks