Comparison of IgA Levels in the Bronchoalveolar Lavage Fluid of Patients With and Without Antibiotic Therapy

Medical University of Vienna20 enrolled

Overview

Investigators hypothesize that Immunoglobine (Ig) production is influenced by the microbiota of the gut. Investigators will compare microbiota-dependent Ig production in the bronchoalveolar lavage fluid of patients with and without antibiotic therapy in order to detect significant differences.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Immunoglobulin A

Interventions

Anti-Bacterial AgentsDRUG

administration of any antibiotic substance(s) over the course of 2 weeks

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * endotracheal intubation * antibiotic therapy for 2 weeks OR no antibiotic therapy for at least 3 months Exclusion Criteria: * active infection * pregnancy * immunodeficiency

Locations (1)

Medical University of Vienna

Vienna, Austria

Outcomes

Primary Outcomes

IgA levels in the bronchoalveolar lavage fluid

Time frame: 2 weeks of ICU stay

Secondary Outcomes

number of detected bacterial, viral, and fungal infections per patient

Time frame: through study completion, an average of 2 months

Data from ClinicalTrials.gov

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