Efficacy and Safety of Young Health Plasma on Acute Stroke

Inclusion Criteria: * Age 65-80 years * Clinical presentation of spontaneous intracerebral hemorrhage/ischemic stroke * CT/MRI/MRA scan compatible with spontaneous intracerebral hemorrhage/ ischemic stroke * Time to young plasma treatment \< 72 h from symptom onset * Glasgow Coma Score \> 6 on initial presentation or improvement to a Glasgow Coma Score \> 6 within the time frame for enrollment * The first-ever primary supratentorial intracerebral basal ganglia hemorrhage 5-30ml * Signed and dated informed consent is obtained * TOAST: Large-artery atherosclerosis Exclusion Criteria: * Patients who will undergo surgical evacuation of intracerebral hemorrhage/ischemic stroke * Inability to undergo neuroimaging with Magnetic Resonance * Glasgow Coma Score \< 6 * Significant past history of disability, modified Rankin Scale（mRS）≥1 * Primary intraventricular hemorrhage ICH due to coagulopathy (PT \> 15 s or International Normalized Ratio \> 1.3, Partial Thromboplastin Time \> 36) or trauma * Thrombocytopenia: platelet count \<100 000 * Clinically significant hepatic disease as demonstrated by history, clinical exam (ascites, varices), or laboratory findings (LFTs \>2x normal, coagulopathy as described) * Comorbid conditions likely to complicate therapy including but not limited to the following: a history of New York Heart Association class II, III, or IV Congestive Heart Failure; end-stage acquired immune deficiency syndrome * Known pregnancy, or positive pregnancy test, or breast feeding * Malignancy (history of or active) * Bradyarrhythmia and Atrioventricular Block * Concomitant use with antineoplastic,immunosuppressive or immune modulating therapies * Macular Edema * Life expectancy of less than 90 days due to comorbid conditions * Occurrences of secondary intracerebral hemorrhage/ischemic stroke * Patients known or suspected of not being able to comply with the study protocol due to alcoholism, drug dependency, noncompliance, living in another state or any other cause