The purpose of the present investigation is to record and compare bacterial compositions in subgingival plaque samples and saliva samples in subjects receiving periodontal treatment. The hypothesis is that the composition of the salivary microbiota might reflect local bacterial alterations in relation to periodontal treatment.
In this study we plan to enroll 35 subjects with manifest periodontitis, which will be treated according to national and international guidelines. Clinical registration and collection of subgingival plaque samples and saliva samples will be performed at baseline and 2, 6 and 12 weeks after treatment.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
DIAGNOSTIC
Masking
NONE
Enrollment
30
Non-surgical periodontal treatment including thorough instruction in self-performed oral hygiene
University of Copenhagen, Department of Odontology
Copenhagen, Copenhagen, Denmark
Changes in α-diversity in saliva samples collected .
Comparison of α-diversity in saliva samples collected before periodontal treatment and 12 weeks after treatment
Time frame: Baseline and 12 weeks
Specis specific changes in saliva samples collected
Comparison of relative abundance of bacterial species in saliva samples collected before periodontal treatment to samples collected 12 weeks after treatment
Time frame: Baseline and 12 weeks
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.