Cardiovascular Variability and Heart Rate Arousal Response in Idiopathic Hypersomnia

Centre Hospitalier Universitaire de Saint Etienne33 enrolled

Overview

Autonomic nervous system dysfunction has been described in narcolepsy with cataplexy affecting the sympathetic function. In this study the investigators analyzed whether altered diurnal and nocturnal cardiovascular control is present in idiopathic hypersomnia. Drug-free patients diagnosed with idiopathic hypersomnia and age-matched controls were included. Clinical data, 24-h polysomnography, heart rate variability and the heart rate response to spontaneous arousal are analyzed.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Narcolepsy Cataplexy

Interventions

PolysomnographyDEVICE

The polysomnography, for both groups, was performed accordance with standard practice

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: Idiopathic hypersomnia patients * idiopathic hypersomnia diagnosis * complaints of excessive daytime sleepiness for \>1 year * a night-time length \>10 h for 3 weeks before polysomnography as assessed by a sleep diary Inclusion Criteria: no idiopathic hypersomnia patients * no sleep complaints and excessive daytime sleepiness (Epworth sleep questionnaire score \<10 Exclusion Criteria (both): * Narcolepsy-cataplexy * sleep irregularities and sleep deprivation symptoms * lack of neurological or psychiatric diseases * upper airway resistance syndrome * periodic limbs movements * cerebral lesion * medication or drinks affecting sleep and wake state

Locations (1)

CHU de SAINT-ETIENNE

Saint-Etienne, France

Outcomes

Primary Outcomes

High Frequencies (HF)

Nocturnal parasympathetic activity (HF parameter of heart rate variability analysis)

Time frame: During the polysomnography (one night)

Secondary Outcomes

Heart rate variability (HRV)

HRV is measured by the polysomnography. It is a composite outcome : Standard Deviation of NN intervals (SDNN), the proportion of NN30 (and 50) divided by total number of NNs (pNN30, pNN50), Root Mean Square of Successive Differences (RMSSD), Standard Deviation type 1 and 2 (SD1, SD2), Low Frequencies (LF), Very Low Frequencies (VLF), LF/HF ratio and Ptot indexes

Time frame: During the polysomnography (one night)

Apnea-Hypopnea Index (AIH)

Time frame: During the polysomnography (one night)

Epworth Sleepiness Scale (ESS)

It examines eight different situations using a 4-grade scale ranging from 0 (no chances of napping) to 3 (high chances of napping). Subjects were defined as sleepy if they had an ESS\>10

Time frame: Before the polysomnography (one night)

Data from ClinicalTrials.gov

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