Reduction in Spinal-induced Hypotension With Ondansetron in Parturients Undergoing Caesarean Section

Assiut University160 enrolled

Overview

Subarachnoid block is the preferred method of anaesthesia for caesarean section, but is associated with hypotension and bradycardia, which may be deleterious to both parturient and baby. Animal studies suggest that in the presence of decreased blood volume, 5-HT may be an important factor inducing the Bezold Jarisch reflex via 5-HT3 receptors located in intracardiac vagal nerve endings. In this study, the investigators evaluated the effect of ondansetron, as a 5-HT3 receptor antagonist, on the haemodynamic response following subarachnoid block in parturients undergoing elective caesarean section.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

DOUBLE

Enrollment

160

Conditions

Hypotension

Interventions

Ondansetron

Eligibility

Sex: FEMALEMin age: 18 YearsMax age: 40 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Undergoing an elective lower segment caesarean section. Exclusion Criteria: * Patients with contraindications to subarachnoid block (patient refusal, unstable haemodynamics, coagulation abnormality), * History of hypersensitivity to ondansetron or local anaesthetic agents, * Hypertensive disorders of pregnancy, * Cardiovascular insufficiency, * Receiving selective serotonin reuptake inhibitors or migraine medications.

Outcomes

Primary Outcomes

Hypotension

Systolic BP \<90 mmHg or Diastolic BP \<60 mmHg

Time frame: intraoperative

Secondary Outcomes

Bradycardia

HR \<50 beats/min